Rifampin Enhances the Activity of Amphotericin B against Fusarium solani Species Complex and Aspergillus flavus Species Complex Isolates from Keratitis Patients

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Four new Fusarium species from Fusarium solani species complex isolated from soil

One hundred isolates of Fusarium solani species complex were isolated and identified from 58 agricultural soil samples collected from different geographical regions in Kermanshah, Hamadan and Kurdistan provinces of Iran. Based on morphological characteristics, Fusarium falciforme, F. petroliphilum, F. keratoplasticum and F. pseudensiforme, are reported for the first time from Iran.

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Activity of amphotericin B, 5-fluorocytosine, and rifampin against six clinical isolates of Aspergillus.

Amphotericin B in combination with 5-fluorocytosine was synergistic against three clinical isolates of Aspergillus fumigatus and one of three clinical isolates of A. flavus. Amphotericin B in combination with rifampin was synergistic against all six clinical isolates of Aspergillus tested. The levels of 5-fluorocytosine and rifampin required for synergism were higher than clinically achievable ...

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Synergistic action of amphotericin B and rifampin against Rhizopus species.

A 16-year-old diabetic patient developed Rhizopus pneumonia and was initially treated with amphotericin B for 7 days. Because of clinical deterioration of the patient, rifampin was added empirically. The patient improved clinically, and lung tissue removed surgically 8 weeks later showed no fungal elements by histopathological studies or by culture. An in vitro study of amphotericin B alone and...

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Microdilution susceptibility testing of amphotericin B, itraconazole, and voriconazole against clinical isolates of Aspergillus and Fusarium species.

We compared the activities of amphotericin B, itraconazole, and voriconazole against clinical Aspergillus (n = 82) and Fusarium (n = 22) isolates by a microdilution method adopted from the National Committee for Clinical Laboratory Standards (NCCLS-M27A). RPMI 1640 (RPMI), RPMI 1640 supplemented to 2% glucose (RPMI-2), and antibiotic medium 3 supplemented to 2% glucose (AM3) were used as test m...

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In Vitro Activities of Amphotericin-b in Combination with Rifampin against Aspergillus Species

Objective: The main goal of study was finding the synergism effect of amphotricin B (AMB) and rifampin (RIF) on 3 species of Aspergillus. Methodology: Activities of amphotericin B in combination with rifampin were tested in buffered yeast-nitrogen base using checkerboard method. Plates were inoculated with 20μl spores suspensions of each organism and incubated at 30°C for 24h. For this method, ...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 2017

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.02069-16